PhD Student in Non-Coding Cancer Biology

We are looking for a PhD student in the field of molecular cancer biology to join our new Junior Research Group “Non-Coding Cancer Biology” within the Institute of Pathology.
Our lab investigates the role of the non-coding genome in cancer. We use genome-wide CRISPRi screens to identify oncogenic super-enhancers that are essential to cancer cell survival with the goal of identifying new therapeutic targets. Using novel Cas13d-based screening methods and antisense oligo technology, we then pinpoint specific non-coding transcripts within these essential super-enhancers for therapeutic exploitation. This strategy lays the groundwork for first-of-its-kind precision epigenetic therapies and introduces a paradigm-shifting framework for exploiting the non-coding genome in oncology.

Your Tasks

As a PhD student in our research team you will have the unique opportunity to:

• Gain expertise in the exciting and novel area of non-coding regulatory genomics and epigenomics
• Learn and employ cutting-edge CRISPR methods including epigenome editing, CRISPR-based live-cell imaging, and RNA-targeting CRISPR
• Perform next-generation CRISPR screens including CRISPRi, CRISPRa, and RNA-targeting CRISPR systems (Cas13d)
• Employ bioinformatics platforms and computational pipelines for the analysis of CRISPR screening, RNA sequencing, DNA sequencing, and ChIP-seq datasets
• Experience research at the interface between experimental and computational biology
• Interact within a diverse and multidisciplinary environment of biologists, clinicians, pathologists, and computational scientists within the DKTK network and the LMU Munich

Your Profile

We are looking for a talented and enthusiastic doctoral candidate who is highly motivated to make a meaningful contribution to cancer research. Previous exposure to and experience with basic molecular biology techniques, cell culture, CRISPR, and bioinformatics as well as a profound interest in cancer and genome biology are essential.

You should hold a diploma or master’s degree in biochemistry, biology, molecular/translational medicine, or related subjects. Due to the interdisciplinary framework and close collaboration between wet-lab and computational scientists, good communicative skills as well as fluency in English are essential. Good written and spoken German skills are also required.

We Offer

Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level

Access to international research networks

Doctoral salary with the usual social benefits

30 days of vacation per year

Flexible working hours

Possibility of part-time work

Family-friendly working environment

Sustainable travel to work: subsidized Germany job ticket

Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service

Our Corporate Health Management Program offers a holistic approach to your well-being